Welcome to the Zhang research group!
Prof. Zhang is currently affiliated with Shanghai Jiao Tong University. During this transition period, the Zhang lab in Tianjin continues to thrive under his guidance, while the new Zhang lab in Shanghai has begun its operations and is growing in size.
欢迎访问张雁课题组！
General Description
The Zhang research group has a long term interest in metalloenzymes, radical enzymes, and their catalytic mechanisms. We combine chemically guided bioinformatics and biochemistry to explore new enzymes and new metabolic pathways in microbes. Other projects in our laboratory include synthetic biology, immuno-based human disease diagnosis and new drug development.
张雁课题组长期致力于金属酶、自由基酶及其催化机制的研究。课题组将化学引导的生物信息学和生物化学相结合，探索微生物中新的酶和新的代谢途径。课题组的其他研究方向还包括合成生物学、基于免疫的人类疾病诊断和新药研发。
News
2024
Congratulations to Yiwei Chen for his paper published in iScience
Congratulations to Kailiang Ma for his paper published in J Am Chem Soc
Congratulations to Prof. Yang Tong for receiving the fund of the General Program of the National Natural Science Foundation of China
Congratulations to Dr. Yiling Hu for receiving the fund of the Youth Program of the National Natural Science Foundation of China
Congratulations to Chunxiu Liu for her paper published in Journal of Biological Chemistry
Congratulations to Li Jiang for her paper published in ACS Catalysis
2023
Congratulations to Prof. Yan Zhang for receiving the fund of New Cornerstone Investigator Program (2023 新基石研究员项目)
Congratulations to Yang Tong for her paper published in Cell Chem Biol.
Congratulations to Yang Tong for her paper published in Nat Microbiol.
2022
Congratulations to Yongxu Duan for her paper published in J Am Chem Soc
2021
Congratulations to Jiayi Liu, Kailiang Ma, Junwei An for their paper published in ACS Catalysis
Congratulations to Prof. Yan Zhang for receiving the National Science Fund for Distinguished Young Scholars of China (2021 国家自然科学杰出青年基金)
Congratulations to Haibin Zhang for her paper published in ACS Catalysis
Congratulations to Yan Zhou for his paper published in Science
Congratulations to Qiang Lu for his paper published in ACS Catalysis
Research
Glycyl Radical Enzymes (GREs)
Sulfonate degradation by strictly anaerobic bacteria was recently found to involve C–S bond cleavage through O2-sensitive free radical chemistry, catalyzed by glycyl radical enzymes (GREs)… [read more]
Pyrimidine degradation pathways
Pyrimidine degradative pathways are widespread among living organisms, enabling intracellular recycling of pyrimidines or utilization of pyrimidines as substrates for growth… [read more]
Purine degradation pathways
Here we report the identification
and characterization of these enzymes… [read more]
Sulfonate metabolism
Here, we report the discovery of three
additional sulfoglycolysis pathways… [read more]
Synthetic Biology
Rose has been entwined with human culture and history. “Blue rose” in English signifies unattainable hope or an impossible mission as it does not exist naturally and is not breedable regardless of centuries of effort by gardeners… [read more]
Find Us
Send emails to Prof. Yan Zhang, yan.zhang@tju.edu.cn, 417-4, Bldg. 24, Tianjin University, 92 Weijin Rd, Tianjin, China
or Send emails to Prof. Yan Zhang, zhangyan.ny@sjtu.edu.cn, 4C-17, Bidg of Life Sciences and Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Rd, Shanghai, China
