Welcome to the Zhang lab at the School of Pharmaceutical Science and Technology, Tianjin University! 欢迎来到天津大学药学院张雁实验室
General Description
The Zhang group has a long term interest in metalloenzymes, radical enzymes, and their catalytic mechanisms. We combine chemically guided bioinformatics and biochemistry to explore new enzymes and new metabolic pathways in microbes. Other projects in our laboratory include synthetic biology, immuno-based human disease diagnosis and new drug development.
张雁课题组长期致力于金属酶、自由基酶及其催化机制的研究。课题组将化学引导的生物信息学和生物化学相结合，探索微生物中新的酶和新的代谢途径。课题组的其他研究方向还包括合成生物学、基于免疫的人类疾病诊断和新药研发。
News
2024
Congratulations to Jiang Li for her paper published in ACS Catalysis
2023
Congratulations to Prof. Yan Zhang for receiving the fund of New Cornerstone Investigator Program (2023 新基石研究员项目)
Congratulations to Tong Yang for her paper published in Cell Chem Biol.
Congratulations to Tong Yang for her paper published in Nat Microbiol.
2022
Congratulations to Duan Yongxu for her paper published in J Am Chem Soc
2021
Congratulations to Liu Jiayi, Ma Kailiang, An Junwei for their paper published in ACS Catalysis
Congratulations to Prof. Yan Zhang for receiving the National Science Fund for Distinguished Young Scholars of China (2021 国家自然科学杰出青年基金)
Congratulations to Zhang Haibin for her paper published in ACS Catalysis
Congratulations to Zhou Yan for his paper published in Science
Congratulations to Lu Qiang for his paper published in ACS Catalysis
Research
Glycyl Radical Enzymes (GREs)
Sulfonate degradation by strictly anaerobic bacteria was recently found to involve C–S bond cleavage through O2-sensitive free radical chemistry, catalyzed by glycyl radical enzymes (GREs)… [read more]
Pyrimidine degradation pathways
Pyrimidine degradative pathways are widespread among living organisms, enabling intracellular recycling of pyrimidines or utilization of pyrimidines as substrates for growth… [read more]
Purine degradation pathways
Here we report the identification
and characterization of these enzymes… [read more]
Sulfonate metabolism
Here, we report the discovery of three
additional sulfoglycolysis pathways… [read more]
Synthetic Biology
Rose has been entwined with human culture and history. “Blue rose” in English signifies unattainable hope or an impossible mission as it does not exist naturally and is not breedable regardless of centuries of effort by gardeners… [read more]
Find Us
Send emails to Prof Zhang Yan, yan.zhang@tju.edu.cn, 417-4, Bldg. 24, Tianjin University, 92 Weijin Rd, Tianjin, China
